マウスにおけるインスリンシグナル伝達の代替経路で,IRS-1遺伝子の標的を絞った中断を伴う

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Updated: Oct 1, 2026

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
09:13

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy

Published on: November 1, 2011

E Araki1, M A Lipes, M E Patti

  • 1Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215.

Nature
|November 10, 1994
PubMed
まとめ

インスリン受容体基板-1 (IRS-1) が欠けていたマウスは,成長障害とグルコース耐性を示した. この研究は,インスリン/IGF-1シグナル伝達におけるIRS-1-依存および独立経路を明らかにしています.

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