原発性乳がんにおけるCD44変異のエクソンエピトープと生存期間
M Kaufmann1, K H Heider, H P Sinn
1Department of Obstetrics and Gynaecology, University of Heidelberg, Germany.
Lancet (London, England)
|March 11, 1995
まとめ
乳がんにおけるCD44変異エクソンv6発現は,予後が悪いことを示している. このCD44エピトープは,侵襲性乳がん患者の生存の有意な独立した予測因子である.
科学分野:
- 腫瘍学 腫瘍学
- 分子生物学は分子生物学である.
- がん研究 がん研究
背景:
- CD44は,代替スプライシングで生成される細胞表面タンパク質ファミリーです.
- エクソンv6配列を含むスプライス変種は,動物がんモデルにおける転移と関連している.
研究 の 目的:
- ヒト乳がんにおけるCD44変異エクソン表皮トープ発現を評価する.
- 乳がん患者におけるこれらのエピトープの予後の可能性を決定する.
主な方法:
- ヒトCD44変異エクソン配列に対する親和性浄化ポリクローン血清とモノクローン抗体を使用した.
- 100の原発的侵襲性乳房腫瘍,再発,転移,および正常組織におけるCD44発現を調査した.
主要な成果:
- CD44変異のエクソン (v3,v5,v6) は,ほとんどの腫瘍で発現したが,正常な乳腺管内皮質細胞や多発性病変では発現しなかった.
- DIIIエピトープ (エクソンv6) は,原発性腫瘍の84%と転移の100%で発見されました.
- エクソンv6陽性腫瘍は,著しく低い全生存率 (p=0.005) と相関していた.
結論:
- CD44変異エクソン発現,特にエクソンv6エピトープは,乳がんにおける貴重な予後マーカーである.
- CD44エクソンv6エピトープは,腫瘍のサイズ,グレード,リンパ節の状態,またはプロゲステロン受容体のレベルに影響を受けない,予測の独立した予測因子です.
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