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Updated: Aug 10, 2026

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FGF結合とFGF受容体の活性化は,合成ヘパラン由来二,三糖化物によって行われる

D M Ornitz1, A B Herr, M Nilsson

  • 1Department of Molecular Biology and Pharmacology, Washington University Medical School, St. Louis, MO 63110, USA.

Science (New York, N.Y.)
|April 21, 1995
PubMed
まとめ

線維細胞成長因子 (FGF) はシグナル伝達を活性化するためにヘパリンまたはヘパラン硫酸塩 (HS) を必要とします. 小型の合成HSオリゴサッカリドがFGFを活性化することが判明し,FGFの活性化を調節する結合部位とメカニズムを明らかにした.

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