低血清コレステロールと死亡率. どちらが原因で,どちらが結果なのか?
C Iribarren1, D M Reed, R Chen
1Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles 90033, USA.
Circulation
|November 1, 1995
まとめ
総コレステロール (TC) の低下は,直接的な危険因子ではなく,基礎疾患を示す可能性があります. TC濃度の低下は,日本系アメリカ人男性における特定の癌および非癌の原因による死亡率の増加と関連していました.
科学分野:
- エピデミオロジー エピデミオロジー
- ゲロントロジーはゲロントロジーの学科です.
- バイオマーカー バイオマーカー
背景:
- 研究では,低総コレステロール (TC) と非動脈硬化性疾患との関連が示唆されています.
- 低TCと病気の間の因果関係は不明である:それはリスク要因か結果か?
研究 の 目的:
- 時間の経過によるTC変化と,その後の死亡率との関係を分析する.
- TCの低下がオカルト疾患のマーカーであるという仮説を調査する.
主な方法:
- 日本系アメリカ人男性 (n=5941) の6年間のTC変化の分析.
- 生存分析を用いて16年後の死亡率との関係で,検査されたTCの変化.
- 参加者は,発症時点での年齢は45~68歳であり,主要な疾患はありませんでした.
主要な成果:
- TC値の低下は,特定の癌 (血液形成,食道,前立腺) および非癌原因 (肝臓疾患) の死亡リスクの増加と関連していました.
- すべての原因による死亡リスクは,中から低いTCレベルまで低下した男性では30%高かった.
- 安定した低TCレベルを持つ男性では,死亡リスクの増加は観察されなかった.
結論:
- 発見は,逆因果関係仮説を裏付ける:触媒疾患はTCレベルを低下させる可能性があります.
- TCの低下は,死亡率の独立した危険因子ではなく,基礎疾患の結果である可能性が高い.
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