T細胞の活性化に関与する新しい受容体
B G Cocks1, C C Chang, J M Carballido
1DNAX Research Institute of Molecular and Cellular Biology, Human Immunology Department, Palo Alto, California 94304-1104, USA.
Nature
|July 20, 1995
まとめ
研究者らは,新しいT細胞受容体SLAMを発見し,CD28共刺激経路とは無関係にT細胞の膨張とインターフェロン-ガンマ生成を高める. この発見は,T細胞の免疫応答の調節のための新しい道を開く.
科学分野:
- 免疫学 免疫学とは
- 分子生物学は分子生物学である.
- 細胞生物学 細胞生物学
背景:
- T細胞の活性化には,T細胞受容体と共刺激信号が必要です.
- CD28は主要な共刺激分子ですが,すべてのT細胞反応には不可欠ではありません.
- 代替のT細胞共刺激経路の存在が示唆されている.
研究 の 目的:
- T細胞共刺激に関与する新しい分子を特定し,特徴づけること.
- 新しく特定されたグリコタンパク質,SLAMがT細胞活性化における役割を調査する.
- T細胞反応におけるSLAMのシグナル伝達経路を解明する.
主な方法:
- 新型グリコタンパク質 (SLAM) の識別と特徴付け.
- 様々なT細胞集団におけるSLAM発現の分析.
- SLAMの関与がT細胞増殖とサイトカイン生成に及ぼす影響を調査する.
- SLAM媒介によるT細胞活性化におけるCD28の役割を評価する.
主要な成果:
- SLAM,新しいM(r) 70Kグリコタンパク質が特定され,免疫グロブリン超家族に属しています.
- SLAMは,メモリT細胞,T細胞クローン,チモサイト,B細胞に発現し,活性化時にナイブT細胞に誘発される.
- SLAMのエンゲージメントは,抗原特異性T細胞の増殖とインターフェロン-ガンマ (IFN-ガンマ) 産生をCD28から独立した方法で強化します.
- SLAMはTh0/Th1サイトカインプロファイルを誘導し,Th2クローンでもIFN-ガンマを上調する.
結論:
- SLAMは,T細胞刺激に関与する新しいT細胞受容体です.
- SLAMの関与は,CD28.8とは無関係にT細胞の膨張とIFN-ガンマ生成を強化する.
- SLAMは,T細胞の免疫反応を調節するための新しい経路を表しています.
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