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亜鉛サプリメントが妊娠に与える影響
R L Goldenberg1, T Tamura, Y Neggers
1Department of Obstetrics and Gynecology, University of Alabama at Birmingham 35233-7333, USA.
JAMA
|August 9, 1995
まとめ
妊娠中の亜鉛サプリメントは,胎児の出生体重と頭周りを著しく増加させた. この効果は,ボディマス指数が26kg/m2未満の女性で最も顕著であり,標的の利益を示唆しています.
科学分野:
- 母親と胎児の健康について
- 栄養科学とは,栄養科学である.
- 公衆衛生は公衆衛生である.
背景:
- 母親の栄養は胎児の発達と出産の結果に大きな影響を与えます.
- 亜鉛は胎児の成長と発達に不可欠な微量栄養素です.
- 母親の亜鉛濃度の低下は,妊娠の不良の結果と関連している.
研究 の 目的:
- 妊娠中の亜鉛補給と乳児の出生体重との関連を調査する.
- 頭周回数などの他の新生児の人類測定値に対する亜鉛の影響を評価する.
- 亜鉛の影響に対する母親のボディマス指数の潜在的緩和効果を調査する.
主な方法:
- 580人の妊婦を対象としたランダム化,ダブルブラインド,プラセボ対照試験.
- 参加者は,医学的に貧しい健康なアフリカ系アメリカ人女性で,血亜鉛濃度が平均以下でした.
- 介入は,妊娠19週から出産まで,毎日25mgの亜鉛またはプラセボを含む.
主要な成果:
- 亜鉛サプリメントは,出産時の赤ちゃんの体重 (126g) と頭周長 (0.4cm) を大幅に増加させた.
- ボディマス指数<26kg/m2の女性では,亜鉛は出生時体重を248g,頭周りを0.7cm増加させた.
- 血亜鉛濃度の上昇は,サプリメントを受けたグループで観察されました.
結論:
- 妊娠初期に毎日の亜鉛サプリメント摂取は,赤ちゃんの出生体重と頭周りの周長が改善されたと関連しています.
- 亜鉛の有益な効果は,体重指数が26kg/m2未満の妊婦においてより顕著である.
- 亜鉛サプリメントは,リスク集団における胎児の成長を促進するための貴重な戦略である可能性があります.
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