マンガネスと慢性肝臓脳症

D Krieger¹, S Krieger, O Jansen

¹Department of Neurology, Ruprecht-Karls University of Heidelberg, Germany.

Lancet (London, England)

|July 29, 1995

まとめ

マンガネス (Mn) は,肝不全の患者の基礎性腺に蓄積し,神経毒性を引き起こす可能性があります. この金属の蓄積は,慢性肝臓脳症に役割を果たす可能性があり,新しい治療法を示唆しています.

科学分野:

神経科学は神経科学である.
肝臓病理学肝臓病理学
毒理学毒理学毒理学

背景:

臨床観察と動物研究により,血液中のマンガン (Mn) の値上昇と末期の肝疾患における基礎性ガンジア蓄積との関連が示唆されています.
慢性肝臓脳症 (CHE) は,肝不全に関連した神経精神症候群であり,その根本的なメカニズムは不明です.

研究の目的:

肝機能不全の患者の基礎性ガンジリアにおけるマンガン (Mn) の蓄積を調査する.
慢性肝臓脳症 (CHE) の病原性におけるMnの潜在的な役割を調査する.

主な方法:

磁気共鳴画像 (MRI) を用いて,肝不全の10人の患者と10人の対照群を研究した.
患者および対照群からの全血および脳組織サンプルにおけるMn濃度の測定.

主要な成果:

肝硬変患者の全血中のMn濃度の有意な増加は,対照群と比較して (34.4μg/L vs 10.3μg/L) 観察されました.
MRIにおけるパリダル信号の強さは,血中のMn濃度と相関していた (Rs = 0.8,p = 0.0058).
脳の組織分析では,最多のMn濃度は尾状核で,次に四肢板と白球であることが明らかになった.

結論:

マンガネス (Mn) は,肝硬変の患者の基礎性ガンジュリア内に蓄積することが実証されています.
発見は,Mn神経毒性が慢性肝臓脳病変 (CHE) の病原化に寄与する可能性があることを示唆しています.
CHEの治療戦略として,ケレーティング剤に関するさらなる研究が必要である.

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