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プロトゾアのシリアス動物Euplotes raikovioviによって生成されるフェロモンのオトクリンミトゲン活性
A Vallesi1, G Giuli, R A Bradshaw
1Dipartimento di Biologia Molecolare, Cellulare e Animale, University of Camerino, Italy.
Nature
|August 10, 1995
まとめ
シリアスフェロモンは,最初は交配を誘発することが知られているが,また,それらを生成する同じ細胞で植物的繁殖を刺激する. これは,自己認識と成長における古代の役割を示唆し,交尾誘導は後に進化した.
科学分野:
- 細胞生物学 細胞生物学
- プロトゾオロジー プロトゾオロジー
- 進化生物学の進化生物学について
背景:
- シリアスは,交配型を区別するために,拡散性ポリペプチドフェロモンを利用します.
- フェロモンは伝統的に,異なる細胞タイプ間のシグナル伝達によって交配を誘発します.
- オトクリン受容体はフェロモンが交配誘導以外の役割を持つ可能性があることを示唆する.
研究 の 目的:
- シリアスフェロモンのより広範な機能を調査するために.
- Euplotes raikovi.でフェロモンの潜在的オトクリン活性を探求する.
- フェロモン機能の進化的起源を理解するために.
主な方法:
- 海洋シリアートEuplotes raikoviを研究した.
- 細胞の成長に分泌されるフェロモンの影響を調査した.
- 細胞繁殖に関連するフェロモンの活動を分析した.
主要な成果:
- Euplotes raikoviフェロモンが,生殖細胞の植物性繁殖 (ミトジェニック増殖) を促進することを実証した.
- オトクリン活性 (同じ細胞の成長を促す) が主因であることが判明しました.
- パラクリン活動 (外来細胞との交配を誘発する) は二次的機能であるようです.
結論:
- シリアスフェロモンは,植物の成長を促進するオトクリン機能を持っています.
- このオトクリン機能は,これらの分子の祖先の役割を表している可能性があります.
- 進化の変化は,ペロモンのオリジナルの機能を覆い隠し,交配誘導などの新しい役割を獲得したのかもしれない.
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