腹部大動脈動脈瘤の姉妹リスク
P A Baird1, A D Sadovnick, I M Yee
1Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Lancet (London, England)
|September 2, 1995
まとめ
腹部大動脈動脈瘤 (AAA) 患者の一級親族は,AAAを発症するリスクが著しく高い. AAA患者の兄弟姉妹は,早期発症と増加した罹患率のために,超音波による早期スクリーニングが推奨されています.
科学分野:
- 血管外科 血管外科
- 遺伝学 遺伝学とは
- エピデミオロジー エピデミオロジー
背景:
- 腹動脈動脈瘤 (AAA) のリスクは,一級親族で上昇しています.
- AAAの家族集合は,遺伝的成分を示唆しています.
研究 の 目的:
- AAA患者の兄弟姉妹におけるAAAの発症のリスクと年齢を,対照群と比較して調査する.
- この高リスクグループにおける超音波スクリーニングの有用性を評価する.
主な方法:
- AAA受験者の兄弟姉妹 (n=427) と対照患者の兄弟姉妹 (n=451) を比較した3年間の前向きな研究.
- 面接を通じて収集された遺伝情報; 医療記録の検証によって決定される影響を受けた状態.
- 超音波スクリーニングは,兄弟姉妹とコントロールのサブセットで実行されます.
主要な成果:
- AAA試験受験者の兄弟姉妹は,対照兄弟姉妹 (1.1%) よりもAAAの罹患率が高く (4.4%) でした.
- 83歳のAAAの生涯累積リスクは,試験対象者の兄弟姉妹 (11.7%) と対照者の兄弟姉妹 (7.5%) の間で高かった.
- 超音波検査では,検査者の兄弟姉妹 (19%) のAAAの罹患率がコントロール群 (8%) と比べて有意に高いことが明らかになり,早期発症が観察されました.
結論:
- 家族要因は,発症年齢と腹動脈動脈瘤のリスクに大きな影響を与えます.
- AAAと診断された患者の兄弟姉妹は,早期発見を促進するために,定期的な超音波検診が推奨されます.
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