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Updated: Aug 7, 2026

Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes
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遺伝性心律乱症の分子メカニズムについて

P B Bennett1, K Yazawa, N Makita

  • 1Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.

Nature
|August 24, 1995
PubMed
まとめ

SCN5A遺伝子の変異は,ナトリウムチャネル機能を変化させることで,ロングQT症候群3型 (LQT3) を引き起こします. これにより,持続的な内向きのナトリウム電流が発生し,心臓のアクションポテンシャルが延長され,不律症のリスクが増加します.

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