関連する実験動画
Updated: Aug 12, 2026

12:08
Ex Vivo Infection of Live Tissue with Oncolytic Viruses
Published on: June 25, 2011
ウイルス感染症と癌
J D Morris1, A L Eddleston, T Crook
1King's College School of Medicine and Dentistry, Rayne Institute, London, UK.
Lancet (London, England)
|September 16, 1995
まとめ
特定のウイルスの感染は癌につながる可能性がありますが,ウイルスのタンパク質が宿主細胞の腫瘍抑制タンパク質と相互作用した場合のみです. これらのウイルス-宿主相互作用のさらなる理解は,がんの診断と治療において極めて重要です.
科学分野:
- 腫瘍学 腫瘍学
- ウイルス学 ウイルス学 ウイルス学
- 分子生物学は分子生物学である.
背景:
- 特定のウイルス感染症は,ヒトがんの病原性に関与しています.
- 癌の発生率は,ウイルス感染率よりも著しく低く,追加の要因が関与していることを示しています.
研究 の 目的:
- ウイルスががんの発症に寄与する分子メカニズムを探求する.
- ウイルスのタンパク質が宿主細胞の腫瘍抑制タンパク質とどのように相互作用するかを理解する.
主な方法:
- 癌に関連するウイルスの分子分析.
- 宿主細胞のタンパク質とウイルスタンパク質の相互作用の調査.
主要な成果:
- ウイルスは,腫瘍抑制タンパク質に結合し,それを破壊できるタンパク質をコードする.
- これらのウイルスタンパク質は,宿主細胞の成長停止とアポトーシス経路に干渉します.
結論:
- 特定の細胞タイプや免疫不全の宿主におけるウイルスのタンパク質発現は,がんの発症に重要な役割を果たす可能性があります.
- これらのウイルスと宿主との相互作用を理解することは,がんの診断,予後,治療に重大な影響を及ぼします.
関連する概念動画
What is Cancer?
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

