人間の心筋膜における腫瘍死滅因子受容体の発現と機能的意義
G Torre-Amione1, S Kapadia, J Lee
1Cardiology Section, Veterans Administration Medical Center, Houston, TX 77030, USA.
Circulation
|September 15, 1995
まとめ
腫瘍死滅因子α (TNF-α) 受容体,TNFR1とTNFR2は,成人心臓に存在しています. TNFアルファは,TNFアルファと一致しています.
科学分野:
- 心血管生物学 心血管生物学
- 免疫学 免疫学とは
- 分子心臓病学 分子心臓病学
背景:
- 腫瘍死滅因子-アルファ (TNF-alpha) は,心臓病に関与する炎症性サイトカインです.
- TNF-αは,TNFR1およびTNFR2受容体を通してその効果を発揮する.
- 成人哺乳類の心臓におけるTNF受容体の役割は,これまで研究されていなかった.
研究 の 目的:
- 大人の心臓におけるTNF受容体の存在と重要性を調査する.
- TNF-αの負のイノトロプ効果を媒介する特定の受容体を決定する.
主な方法:
- 成人の心臓組織におけるTNFR1およびTNFR2mRNAおよびタンパク質の検出.
- 心筋細胞への受容体の免疫ヒストケミカル局所化.
- 選択的なTNF-α変異体による細胞運動測定を用いた機能評価.
主要な成果:
- 大人の心臓は,TNFR1とTNFR2の両方のmRNAと受容体タンパク質を発現します.
- TNFR1とTNFR2は,心筋細胞に局在していた.
- TNFR1に結合するTNF-α変異体は,ネガティブなイノトロピー効果を模倣したが,TNFR2変異体は効果がなかった.
結論:
- 大人の人の心臓はTNFR1とTNFR2.2の両方を発現します.
- 成人心筋細胞におけるTNF-αの負の内向性作用は,TNFR1の活性化によって引き起こされる.
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