不安定なアンギナと有意な冠動脈疾患の患者で,早朝,不血症の値の低下
1Unitat Coronària, Hospital General Vall d'Hebron, Barcelona, Spain.
Circulation
|October 1, 1995
まとめ
不安定性アンギナを持つ患者は,朝,低血圧の値を経験し,心筋不全のリスクを高めます. これは,冠動脈血管拡張能力の低下または冠動脈トーンズの増加が原因である可能性を示唆しています.
科学分野:
- 心臓病学 心臓病学
- 心血管生理学 心血管の生理学
背景:
- 不安定なアンギナと有意な冠動脈狭窄症の患者は,早朝,心筋不全のピークを示します.
- 不安定性アンギナ患者におけるこの増加した朝の缺血発生の背後にあるメカニズムは,安定性アンギナで観察された同様のパターンにもかかわらず,完全に理解されていません.
研究 の 目的:
- 不安定性胸痛患者における早朝の心筋梗塞不全のピークが低下した心筋不全の値と関連しているかどうかを調査する.
- 不安定性アンギナにおける増加した朝の缺血エピソードの根本的なメカニズムを探求する.
主な方法:
- 重要な冠動脈狭窄症 (>70%) を有する46人の不安定な心房痛患者で,心房ペースを使用して評価された性不全の値.
- 測定は午前7時~8時と午後12時~12時に行われました.
- ペースアップ中に評価されたSTセグメントのシフト,心拍数,および下静脈血圧の反応.
主要な成果:
- 34人の患者で,陽性なペースレスポンスの患者で,午後 (139 bpm) と比較して,午前 (131 bpm) で有意に低い低血圧値が観察されました (P < .001).
- 4人の患者は,朝のペースアップ中にSTセグメントの上昇を経験し,午後は1人だけでした.
- ベースラインの心拍数とダイアストリック血圧は,午前中に有意に上昇しなかった.
結論:
- 心拍数や血圧の変化とは無関係に,早朝の不全値の低下は,冠動脈血管拡張の障害や冠動脈トーンズの上昇を示唆する.
- これらの要因は,不安定な胸痛患者の午前間隔で観察される心筋不全イベントの発生率の増加に寄与する可能性があります.
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