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Updated: Jul 31, 2026

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels
10:07

High-throughput Screening for Small-molecule Modulators of Inward Rectifier Potassium Channels

Published on: January 27, 2013

ナトリウレチンペプチドによるカリウムチャネルの刺激は,cGMPに依存した脱リン酸化を介して行われる

R E White1, A B Lee, A D Shcherbatko

  • 1Laboratory of Cellular and Molecular Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.

Nature
|January 21, 1993
PubMed
まとめ

ナトリウレチンペプチドは,サイクルグアナシンモノフォスファート (cGMP) を通じてホルモンの放出に影響を与えます. この研究は,心房内ナトリウレチンペプチドが,cGMP依存型タンパク質キナーゼとタンパク質脱リン酸化によって介される,下垂体細胞のBKチャネルを刺激することを明らかにしています.

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