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T Cells Capture Bacteria by Transinfection from Dendritic Cells
Published on: January 13, 2016
バクテリア抗原のファゴサイト処理は,T細胞へのクラスI MHCプレゼンテーションのためのT細胞へのファゴサイト処理である
J D Pfeifer1, M J Wick, R L Roberts
1Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110.
Nature
|January 28, 1993
まとめ
バクテリアのファゴサイトーシスは,細胞溶液の侵入なしに,クラスIメジャーヒストコンパティビリティコンプレックス (MHC) 分子による抗原のプレゼンテーションを誘発することができます. これは,外来ファゴサイト性抗原を処理するための新しい真空経路を示唆しています.
科学分野:
- 免疫学 免疫学とは
- 細胞生物学 細胞生物学
背景:
- クラスIメジャーヒストコンパティビリティコンプレックス (MHC) 分子は,通常,内生抗原を呈する.
- 外因的抗原,特に溶解性抗原は,クラスIのMHC分子によって劣悪に提示され,CD8T細胞応答を効果的に誘導しない.
- 微粒子の抗原はCD8T細胞の反応を誘発することができるが,根底にある抗原処理機構は不明である.
研究 の 目的:
- ファゴサイト化粒子の抗原がクラスIのMHC分子によって提示されるメカニズムを調査する.
- 特殊な抗原,特にバクテリアからの抗原が,クラスIのMHCプレゼンテーションのための非古典的な経路で処理できるかどうかを決定する.
主な方法:
- サイトゾール浸透のための既知のメカニズムがないバクテリアのファゴシトーシスを利用した.
- クラスIのMHC分子による抗原プレゼンテーションの評価.
- サイクロヘキシミドとブレフェルディンAを用いて,古典的な抗原処理経路の関与を調査した.
主要な成果:
- バクテリアのファゴサイトーシスは,クラスIのMHC分子によってバクテリアの抗原のプレゼンテーションをもたらしました.
- この抗原伝達経路は,クラシック経路の阻害体であるサイクロヘキシミドとブレフェルジンAに耐性がある.
- 外的ファゴサイト性抗原は,細胞溶液のエントリーとは無関係に処理され,提示されることが示された.
結論:
- クラスIのMHCプレゼンテーションのための外来ファゴサイト性抗原を処理するための新しい真空経路が存在する.
- この経路は,従来の細胞溶液処理経路を回避する.
- 細胞外病原体に対するCD8T細胞の反応を開始するための新しいメカニズムを強調しています.
関連する概念動画
Cell-mediated Immune Responses
Overview
Cells of the Innate Immune Response
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Antigens Involved in Adaptive Immunity
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Antigen Presenting Cells
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
Antigen Processing Pathways
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
MHC Class I: Presenting Endogenous...
Defense Against Bacterial Pathogens
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...

