PI3K SH3ドメインの構造と,SH3ファミリーの分析

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Updated: Mar 29, 2026

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
08:45

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

Published on: July 17, 2020

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S Koyama1, H Yu, D C Dalgarno

  • 1Department of Chemistry, Harvard University, Cambridge, Massachusetts 02138.

Cell
|March 26, 1993
PubMed
まとめ

フォスファディチルイノシトール3キナーゼ (PI3K) SH3ドメインの3次元構造は,配列の違いにもかかわらず,Src SH3ドメインとの構造的類似性を明らかにします. これらの発見は,これらの重要なシグナル伝達タンパク質の間のリガンド結合特性における潜在的な変化を示唆しています.

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