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プロスタグランジン合成阻害剤は,食物不耐症の予防に用いられる
Lancet (London, England)
|April 29, 1978
まとめ
アスピリンなどのプロスタグランジン合成酵素阻害剤の予防用投与は,ほとんどの患者で食物不耐症の症状を予防しました. これらの薬剤は,特定のトリガー食品を避けられない個人に役立つ可能性があり,プロスタグランディンがこれらの反応を媒介することを示唆しています.
科学分野:
- 胃腸内科 胃腸内科
- 薬理学 薬理学とは
背景:
- 特定の食物不耐症は,急性胃腸症状を引き起こす可能性があります.
- プロスタグランジンは,これらの食品誘発反応の媒介に関与しています.
研究 の 目的:
- 食物不耐性を管理するプロスタグランジン合成酵素阻害剤の有効性を調査する.
- 食物に起因する胃腸障害におけるプロスタグランディンの役割を調査する.
主な方法:
- アスピリン,インドメタシン,またはイブプロフェンの予防投与.
- 特定の食品を摂取した後の症状予防の評価.
- プロスタグランジンE2とF2α濃度の測定 血液と便におけるプロスタグランジンE2とF2α濃度の測定 保護されていない食物の挑戦.
主要な成果:
- 6人の患者のうち5人は,予防薬による食物不耐症の症状の予防を経験しました.
- 血と便のプロスタグランディン濃度の上昇は,無防備な挑戦中に症状の発生と相関していた.
- プロスタグランジン合成酵素阻害剤は,予防効果を示した.
結論:
- プロスタグランジン合成酵素阻害剤は,特定の食物不耐症の患者の症状を予防することができます.
- これらの発見は,前列腺素の放出が食物不耐症の症状を媒介するという仮説を支持する.
- プロスタグランジン合成酵素阻害剤は,特定の食物不耐性を管理するための潜在的な治療選択肢を提供します.
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