カナビノイドの周辺受容体の分子特性
S Munro1, K L Thomas, M Abu-Shaar
1MRC Laboratory of Molecular Biology, Cambridge, UK.
Nature
|September 2, 1993
まとめ
研究者らは,臓のマクロファージに新しいカンナビノイド受容体を発見し,それは脳受容体とは異なる. この発見は,カンナビノイドの非精神活性効果を説明し,新しい治療目標を提供することができる.
科学分野:
- 薬理学 薬理学とは
- 免疫学 免疫学とは
- 神経科学は神経科学である.
背景:
- マリファナの主要な成分であるデルタ9テトラヒドロカンナビノール (デルタ9THC) は,歴史的に精神活性剤の用途があります.
- カンナビノイドは,疼痛緩和,抗炎症,抗エメシスなどの多様な効果を示しますが,臨床使用は精神活性によって制限されています.
- 以前特定されたカンナビノイド受容体は主に脳内にあり,非精神活性効果の他のメカニズムを示唆しています.
研究 の 目的:
- カナビノイドの非精神活性効果に関与する新しいカンナビノイド受容体を特定する.
- 既知の脳受容体を超えたカンナビノイド作用の生化学的基礎を解明する.
主な方法:
- カナビノイドのための新しいGタンパク質結合受容体をコードする遺伝子のクローン.
- 免疫細胞を中心に,様々な組織における受容体発現パターンの分析.
主要な成果:
- 新しいカンナビノイド受容体がクローンされ,臓の限界領域内のマクロファージで発現することが判明しました.
- この受容体は特に脳に存在しないため,以前に知られているカンナビノイド受容体とは異なる.
- 低発現は丸では観察されたが,他の周辺組織では観察されなかった.
結論:
- 新しく特定された臓受容体は,カンナビノイドの非精神活性,潜在的に抗炎症または免疫調節効果の一部を媒介する可能性があります.
- この発見は,精神的副作用が軽減されたカンナビノイドベースの治療法を開発するための道を開きます.
- この受容体の免疫機能とカンナビノイドシグナル伝達における役割を完全に理解するために,さらなる研究が必要です.
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