HIV感染におけるサキナビルの安全性と活性
V S Kitchen1, C Skinner, K Ariyoshi
1Department of Genito-Urinary Medicine & Communicable Diseases, St Mary's Hospital Medical School, London, UK.
Lancet (London, England)
|April 15, 1995
まとめ
HIV-プロテインアース阻害剤であるサキナビルは,投与量の範囲を決定する研究で評価されました. 高用量投与は,HIV陽性患者のウイルス負荷を低下させ,CD4数を改善する傾向を示した.
科学分野:
- ウイルス学 ウイルス学 ウイルス学
- 免疫学 免疫学とは
- 薬理学 薬理学とは
背景:
- ヒト免疫不全ウイルス (HIV) 感染症は,世界的な健康問題です.
- 効果的な抗ウイルス治療は,HIVの管理に不可欠です.
- HIV-プロテインアース阻害剤は,ウイルスの複製を標的とする薬物のクラスを表します.
研究 の 目的:
- 経口活性のHIVプロテアゼ阻害剤であるサキナビルの抗ウイルス活性を評価する.
- ジドボウジン未使用のHIV陽性患者におけるサキナビルの耐容性を評価する.
- 抗ウイルス反応と安全性に基づいてサキナビールの最適な用量を決定する.
主な方法:
- ランダム化され,ダブルブラインドで,用量範囲を決定する研究が行われました.
- ジドボウジン未使用の49人のHIV陽性患者で,CD4数 ≤500が登録されました.
- 患者は,サキナビールを25 mg,75 mg,200 mg,または600 mgの投与量で1日3回16週間にわたって投与されました.
主要な成果:
- サキナビールはよく耐えられ,深刻な有害事象は報告されていません.
- CD4細胞数については,投与量-反応関係への傾向が観察され,600 mgの投与量を好みました.
- 周辺血液の単核細胞および血のウイルス負荷は,より高いサキナビル用量で減少する傾向を示した.
結論:
- サキナビルは,HIVに感染した患者で抗ウイルス活性を示しています.
- 600mgの投与量は,CD4カウントの改善とウイルス負荷の減少において有望な傾向を示した.
- サキナビルは,これまで治療を受けていない患者にとって,耐受性が良いHIV-プロテアゼ阻害剤です.
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