イギリスの献血者におけるディフテリア免疫

P A Maple¹, A Efstratiou, R C George

¹Respiratory and Systemic Infection Laboratory, Central Public Health Laboratory, London, UK.

Lancet (London, England)

|April 15, 1995

まとめ

イギリスの成人の多くには,乳頭炎に対する免疫が欠如しており,その感受性は年齢とともに増加しています. 増強免疫は,成人の集団における集団免疫を強化するために推奨されます.

科学分野:

免疫学免疫学とは
公衆衛生は公衆衛生である.

背景:

ディフテリアは依然として公衆衛生上の懸念事項であり,人口の免疫の評価が必要である.
大人の免疫レベルを理解することは,効果的なワクチン接種戦略にとって極めて重要です.

研究の目的:

イギリス生まれの成人の弁炎免疫状態を決定する.
ディフテリア免疫に対する年齢と性の影響を調査する.

主な方法:

イギリスの1000人の献血者 (20~59歳) の血清サンプルを分析した.
Vero細胞ベースの毒素中和測定法により,ディフテリアの抗毒素濃度が測定されました.
ログ・リニアモデルでは,年齢と性別が免疫レベルに与える影響を評価した.

主要な成果:

献血者の37.6%がディフテリアに罹患しやすく,30.9%が完全な保護を受けた.
ディフテリアの免疫は,年齢とともに著しく低下した (p < 0.001).
完全な保護を達成した女性は男性より少ないが,感受性は同様であった.

結論:

イギリスの成人の有意な割合は,十分な弁炎免疫を欠いている.
年齢は重要な要因であり,高齢者はより敏感です.
大人のブースター予防接種プログラムは,人口の免疫を改善し,アウトブレイクを防ぐために不可欠です.

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