糖尿病は臓がんの危険因子である. メタアナリシスです
1Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Md 20892-6600, USA.
JAMA
|May 24, 1995
まとめ
糖尿病は,臓がんのリスクを大幅に増加させます. 長期にわたる糖尿病,特に5年以上にわたる糖尿病は,糖尿病の管理が潜在的に臓がんの発生率を減らすために重要なことを強調し,リスクが倍増することを示しています.
科学分野:
- エピデミオロジー エピデミオロジー
- 腫瘍学 腫瘍学
- エンドクリノロジー エンドクリノロジー
背景:
- 糖尿病は複雑な代謝障害であり,様々な癌と関連している可能性があります.
- 糖尿病と臓がんの関係については議論されており,糖尿病は臓がんの前駆体または結果である可能性があります.
研究 の 目的:
- 臓がんのリスク因子としての糖尿病を調査する.
- 糖尿病を原因と臓がんの症状として区別する.
主な方法:
- 1975年から1994年の間に発表されたケース・コントロールとコホート研究の体系的なレビューとメタ分析.
- 含有基準は,診断または死亡までの少なくとも1年間の糖尿病の持続時間と,計算可能な相対リスク (RR) を要求した.
主要な成果:
- 糖尿病患者の臓がんの相対リスク (RR) は2.1 (95%CI,1.6~2.8) であった.
- コホート研究では,症例対照研究 (1.8) と比較して,より高いRR (2.6) が示されました.
- 糖尿病の持続期間は少なくとも5年であり,RRは2.0 (95%CI,1.2〜3.2) であった.
結論:
- 臓がんの発生率は,長年にわたる糖尿病患者で上昇しています.
- この発見は,糖尿病が臓がんの重要な危険因子であることを示唆しています,特に癌の何年も前に診断された場合です.
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