軸索性化学吸引剤であるネトリン-1は,三角膜運動軸索の化学排斥剤でもある
S A Colamarino1, M Tessier-Lavigne
1Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143-0452, USA.
Cell
|May 19, 1995
まとめ
誘導分子であるネトリン-1は,軸索の発達に起因する化学誘致剤と化学排斥剤の両方として作用する. この二重作用は,脊椎動物の神経管のニューロン成長を誘導し,そのC. elegansの同類であるUNC-6に似ています.
科学分野:
- 神経科学は神経科学である.
- 発達生物学 発達生物学とは
- 分子生物学は分子生物学である.
背景:
- 軸の誘導は,神経回路の形成に不可欠です.
- 拡散性分子は,キモアトラクタントとキモレポレンントとして作用する.
- ネトリン-1は,フロアプレート細胞によって発現される既知の化学吸引剤です.
研究 の 目的:
- トリコリアモーター軸索の誘導におけるネトリン-1の役割を調査する.
- ネトリン-1が二機能的誘導特性を示すかどうかを判断する.
主な方法:
- 発達中の神経管におけるアクソン誘導のインビボ分析.
- COS細胞を利用して,再結合ネトリン-1を分泌する.
主要な成果:
- 床板の細胞は,背中に成長するトルコリアのモーター軸索に長距離の排斥効果を発揮する.
- COS細胞によって分泌されるネトリン-1は,この排斥効果を模倣する.
- ネトリン-1は,いくつかの軸索を惹きつけ,他の軸索を排斥する二重の役割を演じている.
結論:
- ネトリン-1は,脊椎動物の神経系における二機能的誘導シグナルである.
- この二機能性は,C. elegans. のUNC-6で見られるように,種間で保たれています.
- ネトリン-1は,神経の正確な接続を確立する上で重要な役割を果たします.
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