アポトーシスは,ヒトの動脈硬化症とレステノシスで発生する
J M Isner1, M Kearney, S Bortman
1Department of Medicine (Cardiology), St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA.
Circulation
|June 1, 1995
まとめ
アポトーシス,プログラムされた細胞死は,ヒトの大動脈硬化症とレステノシスに存在します. この発見は,アポプトーシスが血管阻害性病変の細胞数を調節するのに役立つことを示唆しています,特に高増殖の病変です.
科学分野:
- 心血管生物学 心血管生物学
- 細胞病理学 細胞病理学
- 血管医学 血管医学とは
背景:
- アポトーシス (プログラムされた細胞死) は,増殖組織における安定した細胞数を維持するために極めて重要です.
- 以前のネズミの研究では,アポプトーシスが,損傷した動脈における滑らかな筋肉細胞の蓄積を軽減することを示唆していた.
- 人間の血管病理学におけるアポトーシスの存在と範囲は未確定のままである.
研究 の 目的:
- 人間の動脈硬化およびレステノティック動脈の標本におけるアポトーシスの発生を調査する.
- アポプトーシスが原発性動脈硬化病変とレステノティック病変の間で異なるかどうかを判断する.
主な方法:
- アテレクトミーを受けた患者の56本の動脈サンプルを免疫ヒスト化学分析.
- サンプルは,主動性動脈硬化病変とレステノティック病変に分類されました.
- 各標本内のアポプトティック細胞の定量化.
主要な成果:
- 研究した標本の63% (35/56) でアポトーシスが検出されました.
- レステノティック病変は,主動性動脈硬化病変 (43% 周辺, 29% 冠動脈) と比較して,アポトーシスの頻度 (93% 周辺, 86% 冠動脈) が著しく高かった.
- アポプトーシスが発生すると,通常は細胞の2%未満が関与します.
結論:
- アポトーシスは,レステノシスと動脈硬化症を含む,ヒトの血管病理学の特徴的な特徴です.
- アポトーシスは,人間の血管阻害性病変の細胞性を調節する役割を果たしているようです.
- アポトーシスの程度は,これらの病変内の増殖活動と関連している可能性があります.
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