アンジオテンシン変換酵素I/Dポリモルフィズムと一般集団における動脈壁の厚さ. ヴォバルノ研究 (英語版)
M Castellano1, M L Muiesan, D Rizzoni
1Center of Hypertension and Cardiorespiratory Risk Factors, University of Brescia, Italy.
Circulation
|June 1, 1995
まとめ
アンジオテンシンI変換酵素 (ACE) DD遺伝子型は,頸動脈の壁の厚さの増加と関連しています. この発見は,ACE DD遺伝子型が心血管疾患の危険因子である可能性があることを示唆しています.
科学分野:
- 心血管遺伝学 心血管遺伝学
- 血管生物学 血管生物学
- 高血圧の研究 高血圧の研究
背景:
- アンジオテンシンI変換酵素 (ACE) 遺伝子の挿入/消去 (I/D) ポリモルフィズム,特にDアレルは,左心室縮などの心血管リスクと関連しています.
- 遺伝的に決定されたレニン-アニオテンシンシステムの過剰活性は,心臓および血管の成長に影響を与える可能性があります.
研究 の 目的:
- ACE I/D遺伝子型と頸動脈の壁の厚さとの関係を調査する.
- 亜臨床性動脈硬化症の潜在的な危険因子としてACE I/D遺伝子型を評価する.
主な方法:
- 一般人口の50〜64歳の199人を対象とした研究.
- 頸動脈のインティマ・メディアの厚さは,Bモード超音波を用いて測定した.
- ACE I/Dポリモルフィズムのゲノタイプ化が行われました.
主要な成果:
- ACEDD遺伝子型は,常軌動脈の内側介質の厚さ (P = .003) の増加と有意に関連していました.
- ACE I/D遺伝子型と大動脈動脈硬化性プラークの存在との間に有意な関連性が見つかりませんでした.
- ACE I/Dゲノタイプは,血圧測定値と相関関係がなかった.
結論:
- ACEDD遺伝子型は,常見の頸動脈内膜介質の濃縮の発症の危険因子として特定される可能性があります.
- これは,心血管リスクに貢献する早期の血管の変化におけるACE遺伝子タイプの潜在的な役割を示唆しています.
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