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Updated: Aug 17, 2026

13:04
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亜鉛と免疫力 タンパク質・エネルギー 栄養不良 栄養不良
Lancet (London, England)
|June 10, 1978
まとめ
栄養不良の子供の亜鉛欠乏は,細胞媒介免疫を損なう. 局所的な亜鉛の適用は,皮膚検査で免疫反応を改善し,亜鉛が示唆された.
科学分野:
- 免疫学 免疫学とは
- 栄養科学とは,栄養科学である.
背景:
- 栄養不良の子どもは,チムスの縮を呈し,亜鉛で逆行する.
- 細胞媒介免疫欠陥は,栄養不良の子供に見られる.
研究 の 目的:
- 亜鉛欠乏症と栄養不良の小児における細胞媒介免疫障害との関連を調査する.
- 延期過敏反応に対する局所的な亜鉛補給の効果を評価する.
主な方法:
- 10人の栄養不良の子供たちは,Candida抗原で皮膚検査を受けました.
- 1つの試験場は局所性亜鉛硫酸塩の軟膏を投与し,もう1つはプラセボを投与した.
- 遅延過敏反応は,両方の部位で測定されました.
主要な成果:
- 亜鉛サプリメントを受けた場所で,遅延過敏反応の有意な増加が観察されました.
- 改善の程度は,血亜鉛濃度と負の相関関係にある.
- これらの発見は,亜鉛欠乏が特に細胞媒介免疫を損なうことを示しています.
結論:
- 亜鉛欠乏症は,栄養不良の子供の免疫不全の直接的な原因です.
- 地元の亜鉛皮膚検査は,亜鉛状態の診断ツールとして役立つかもしれません.
- 亜鉛サプリメントは,この集団における結核などの疾患の診断テストの信頼性を潜在的に高めることができます.
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