夫と妻のクローン病の診断

P J Whorwell, O E Eade, A Hossenbocus

Lancet (London, England)

|July 22, 1978

まとめ

この研究は,結婚して30年以上経った夫と妻の両方にクローン病が発症する珍しい症例について説明しています. 炎症性腸疾患の発症に潜在的に共通する環境的または遺伝的要因を強調しています.

科学分野:

胃腸内科胃腸内科
クリニカル・メディシン臨床医学
エピデミオロジーエピデミオロジー

背景:

クローン病は,複雑な病因を持つ慢性炎症性腸疾患 (IBD) である.
IBDの家族集団化は,遺伝的および/または環境の影響を示唆しています.
長期にわたる結婚カップルのIBDの発生は,まれに報告されています.

研究の目的:

クローン病と診断された夫婦の病歴を紹介するためです.
クローン病の発症における潜在的共同リスク要因を,夫婦の二重関係の中で探求する.

主な方法:

遡及的ケースレビュー.
詳細な臨床履歴と診断ワークアップ分析.
家族および配偶者のIBDに関する関連する文献のレビュー.

主要な成果:

夫も妻も30年以上の結婚生活の後,クローン病を発症しました.
臨床的表象と疾患進行は,両方の個人に記録された.
他の近親にはIBDの歴はありませんでした.

結論:

この長年結婚したカップルのクローン病の同時発生は,共同の環境曝露または遺伝的予備性についてのさらなる調査を正当化します.
このケースは,炎症性腸疾患の配偶者コンコンダンスに関する限られた文献に追加されています.
IBDの病原性における共通因子の役割を明らかにするために,さらなる研究が必要である.

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