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Mycobacterium tuberculosisのイソニアジド標的の結晶構造と機能について

A Dessen1, A Quémard, J S Blanchard

  • 1Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461.

Science (New York, N.Y.)
|March 17, 1995
PubMed
まとめ

結核におけるイソニアジド耐性は,InhAタンパク質の変異と関連しており,NADHを結合する能力に影響する. InhA酵素におけるこの構造の変化は,必須脂肪酸の合成を変化させることで,薬剤の有効性を阻害する.

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