慢性型チフスおよびパラチフス感染者の癌による死亡率
C P Caygill1, M J Hill, M Braddick
1Pathology Division, Public Health Laboratory Service-Centre for Applied Microbiological Research, Porton Down, Wiltshire, UK.
Lancet (London, England)
|January 8, 1994
まとめ
慢性型チフス発症は,胆管がんのリスクを大幅に高めます. 抗生物質または外科手術による長期キャリアの根絶は,がん予防に不可欠です.
科学分野:
- 微生物学 微生物学とは
- 腫瘍学 腫瘍学
- エピデミオロジー エピデミオロジー
背景:
- バクテリアは,体内分泌物から発がん物質を生成することができます.
- 慢性尿路感染症は,発がん物質と関連しています.
- 胆管の感染症と癌のリスクの調査は正当化されています.
研究 の 目的:
- 慢性的な胆管感染症,特にチフス発症の感染が,がんのリスクの増加と関連しているかどうかを判断する.
- 慢性型チフス感染者のがんリスクと,急性型チフス感染者のがんリスクを比較する.
主な方法:
- 慢性型チフスおよびパラチフス感染者のがんリスクを分析した遡及的研究.
- 特定のアウトブレイクからの急性チフス感染症を有する個人のコントロールグループとの比較.
主要な成果:
- 慢性チフス感染者の場合,胆管がんのリスクが著しく高まっていることが示されました (観察/予想される症例: 167.0).
- 臓 (8.1),結腸直腸 (3.0),肺 (2.5) がん,および全体的な腫瘍 (2.6) のリスクの増加も観察されました.
- 同様の過剰ながんリスクは,急性チフス感染の個体でも認められなかった.
結論:
- 急性感染症ではなく,長期にわたるチフス発症は,様々ながん,特に胆管がんの重要な危険因子として特定されています.
- 抗生物質またはコレシステクトミーによる慢性チフス発症の根絶は,がん予防に不可欠です.
- 慢性キャリアの正確な文書化は,公衆衛生イニシアチブにとって不可欠です.
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