変換ゾーンの大回路切除の効果と安全性
A Bigrigg1, D K Haffenden, A L Sheehan
1University Department of Obstetrics and Gynaecology, Southmead Hospital, Bristol, UK.
Lancet (London, England)
|January 1, 1994
まとめ
トランスフォーメーションゾーンの大回路切除 (LLETZ) は,頸部内皮内腫瘍 (CIN) の安全で効果的な治療法です. フォローアップでは,再発率は低く,生育力や月経に悪影響はないことが示されています.
科学分野:
- 婦人科 婦人科について
- 腫瘍学 腫瘍学
- 公共衛生は公衆衛生である.
背景:
- 子宮頸内膜内腫瘍症 (CIN) は,子宮頸部の癌前状態である.
- 変換ゾーンの大回路切除 (LLETZ) は,CIN.の一般的な治療法です.
- LLETZの長期的な有効性と安全性に関するデータは以前は限られていた.
研究 の 目的:
- CIN.の治療におけるLLETZの長期的な有効性と安全性を評価する.
- LLETZ.後に再発率と残留病変率を評価する.
- 女性の生育能力と月経症状に対するLLETZの影響を調査する.
主な方法:
- 1990年の研究では,LLETZで治療を受けた1000人の女性を追跡調査した.
- 子宮頸部サイトロジーは2年以上の追跡のために使用されました.
- アンケートでは,LLETZ投与から3年後の250人の女性の生育能力と月経症状を,対照群と比較して評価した.
主要な成果:
- 再発率と残留病変率は,1年目には5.0%,2年目には0.6%であった.
- LLETZは,繰り返しの処置として有効でしたが,陰性ヒストロジーの比率はより高い (20%対4.7%) でした.
- LLETZ患者と対照群の間では,生育力や月経症状の有意な差異は見つかりませんでした.
結論:
- LLETZは,低長期再発率のCINに対する安全で効果的な治療法です.
- この処置は女性の生育能力や月経周期に悪影響を及ぼさないようです.
- LLETZは,持続的または再発性CIN.の繰り返し処置として安全に使用することができます.
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