生後麻疹の感染と,その後のクローン病
A Ekbom1, A J Wakefield, M Zack
1Cancer Epidemiology Unit, University Hospital, Uppsala, Sweden.
Lancet (London, England)
|August 20, 1994
まとめ
幼児期における麻疹ウイルスへの曝露は,クローン病のリスクを増やす可能性があります. この研究では,麻疹の流行の間に生まれた個人にクローン病の症例がより多く見つかり,関連性があることを示唆しました.
科学分野:
- エピデミオロジー エピデミオロジー
- ウイルス学 ウイルス学 ウイルス学
- 胃腸内科 胃腸内科
背景:
- クローン病の病因は不明である.
- 麻疹ウイルスは,特に生命の初期に暴露された場合,潜在的な寄与因子として関与しています.
- 以前の研究では,麻疹の流行とクローン病の発生率の増加との相関が示唆されています.
研究 の 目的:
- 麻疹の流行とクローン病の発生率との関連を調査する.
- 麻疹の流行中の出産がクローン病を発症するリスクを高めるかどうかを判断する.
- クローン病に関連して,麻疹の曝露に対する生理周期の脆弱性を評価する.
主な方法:
- スウェーデンの4つの郡 (1945年−1954年) で30歳未満でクローン病と診断された個人を特定した.
- 研究期間における麻疹の流行データと出生記録を分析した.
- クローン病および潰瘍性大腸炎の症例の予想対観察を計算し,麻疹の流行のピークから3ヶ月後に生まれ,生児に調整した.
主要な成果:
- クローン病の症例の有意な過剰 (57例観察 vs. 39.0例予想) は,麻疹の流行のピーク (SIR 1.46) の後に生まれた個体で発見されました.
- 潰瘍性大腸炎症例の観察された数 (42) は,予想される数 (46.8) に似ていた.
- 結果は,麻疹の流行と,その後のクローン病の診断との間に統計的に有意な関連があることを示しています.
結論:
- この発見は,麻疹ウイルスをクローン病と結びつける仮説を裏付けている.
- 周産期は,クローン病の発症に関する麻疹曝露の脆弱性の重要な窓であるようです.
- この関連に伴う特定のメカニズムを解明するために,さらなる研究が必要である.
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