血粘性の地理的変動と冠動脈事件の発生率との関係
1Department of Internal Medicine II, Ulm University Medical Centre, Germany.
Lancet (London, England)
|September 10, 1994
まとめ
ドイツのアウグスブルクと比較して,スコットランドの血粘度が高いことは,スコットランドの冠動脈疾患 (CHD) と脳卒中のリスクの増加を部分的に説明する可能性がある. この発見は,心血管疾患の格差の潜在的な要因として,血粘度を強調しています.
科学分野:
- 心血管科学 心血管科学
- エピデミオロジー エピデミオロジー
- バイオメディカルリサーチ
背景:
- 血粘性は,冠動脈性心疾患 (CHD) と脳卒中の既知の予測因子です.
- CHD発生率の地理的変動は,人口特有のリスク要因を暗示しています.
研究 の 目的:
- CHD発生率と血粘度における地域差の相関を調査する.
- 高CHDリスク地域 (スコットランド) と低リスク地域 (ドイツ・アウグスブルク) の血粘度値を比較する.
主な方法:
- グラスゴー (MONICAとスコットランド心臓健康研究) とアウグスブルク (MONICA) で人口を横断的に調査した.
- 血粘性は,25歳から64歳までの男女で測定されました.
- 統計分析は,心血管疾患のリスク因子を調整した平均血粘度を比較した.
主要な成果:
- 平均プラズマ粘度は,アウグスブルク (男性1,261 mPa s,女性1,248 mPa s) と比較して,スコットランド西部 (男性1,327 mPa s,女性1,318 mPa s) で有意に高かった.
- これらの差異は,年齢,喫煙,コレステロール値,血圧,ボディマス指数に合わせて調整した後も持続した.
- グラスゴーでの年齢標準化された冠動脈事件の発生率は,男性と女性の両方にとってアウグスブルクよりも格ラスゴーで大幅に高かった.
結論:
- 血粘度における観測された地理的差異は,スコットランドとアウグスブルク間のCHD発生率の格差に寄与する可能性がある.
- プラズマ粘度の決定因子とその動脈硬化症,血栓症,および缺血における役割について,さらなる研究が必要である.
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