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Updated: Jul 13, 2026

Detection of Neu1 Sialidase Activity in Regulating TOLL-like Receptor Activation
09:04

Detection of Neu1 Sialidase Activity in Regulating TOLL-like Receptor Activation

Published on: September 7, 2010

腫瘍死滅因子シグナル伝達における中性および酸性スフィンゴミエリナーゼの機能的二分法

K Wiegmann1, S Schütze, T Machleidt

  • 1Institut für Medizinische Mikrobiologie und Hygiene, Technische Universität München, Federal Republic of Germany.

Cell
|September 23, 1994
PubMed
まとめ

腫瘍死滅因子 (TNF) は,2種類のスフィンゴミエライナーゼ (SMases) を独立して活性化します. これらの酵素はセラミドを生成し,NF-カッパB活性化やタンパク質キナーゼシグナル伝達などの異なるシグナル伝達経路を制御します.

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