左心室の脱差後における動性心肺反射
1Department of Medicine, Medical College of Virginia/Virginia Commonwealth University, Richmond.
Circulation
|October 1, 1994
まとめ
左心室 (LV) からの帯神経繊維は,腎交感神経活動 (RSNA) の調節におけるその役割を研究するために中断されました. LVインプットの損失は,他の心肺受容体が補償することを示唆する,控えめな効果を持っていた.
科学分野:
- 心血管生理学 心血管の生理学
- 自律神経系の規制について
- 腎臓生理学 腎臓生理学
背景:
- 主に心室からの帯神経繊維は,移植や心筋梗塞などの心臓イベントによって中断されます.
- ヴァガルアフェレント繊維によって媒介される心肺反射の異常は,心臓移植と心筋梗塞後の観察されています.
- これらの反射異常と心室分離の関連性は不明である.
研究 の 目的:
- 左心室 (LV) の分離が腎交感神経活動 (RSNA) の動心肺反射制御に与える影響を調査する.
- 血液動力学的変化に対するRSNA応答を調節する際にLVのヴァーガルアフェレンスのインプットの役割を評価する.
主な方法:
- クロラロース麻酔とシノアオルティック・デナーベーションを用いた犬におけるRSNAの動心肺反射制御を調査した.
- 測定された左心房圧 (LAP) と出血と体積膨張に対するRSNA応答は,フェノールによるLV分離前と後である.
- ソノミクロメトリーを用いて,LV心筋細節の長さを評価し,冠内ニコチンを用いて分離を確認した.
主要な成果:
- LVの脱差は,体積膨張 (P < .05) 時の動性心肺反射感を軽く弱めた (P < .05).
- LV分離後の出血中に,反射感度の有意な変化は観察されなかった.
- 冠内ニコチンはRSNAの分離後抑制に失敗し,効果的な心室分離が確認されました.
結論:
- LVからのヴァーガルアファレントの入力中断は,ヴァーガル心肺反射によるRSNAの制御にわずかな効果しか及ぼさない.
- 動性心肺反射は有意な冗長性を示し,肺および他の心室受容体は,LVアフェレンスの入力損失を補償する.
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