非インディアンの子供の肝硬変は,食中の余分な銅によって引き起こされるのでしょうか?
1National Center for the Study of Wilson's Disease, Columbia University, New York, NY 10019.
Lancet (London, England)
|October 8, 1994
まとめ
非インディアンの子供の肝硬変は,飲料水に含まれる高濃度の銅によって引き起こされるものではありません. 幼児におけるこの肝臓疾患は,実は遺伝的に受け継がれることが示唆されています.
科学分野:
- 肝臓病理学 肝臓病理学
- 環境衛生 環境衛生 環境衛生
- 遺伝学 遺伝学とは
背景:
- インドの子供の肝硬変は,銅器で煮えた牛乳からの過剰な銅の摂取と関連しています.
- インド人以外の子供の肝硬変の症例は,飲料水中の銅に起因し,報告された濃度は0.05から6.8mg Cu/Lの範囲であった.
研究 の 目的:
- 飲料水中の高銅濃度と非インディアンの子供の肝硬変の関連性を調査する.
- 非インディアンの子供の肝硬変の病因的要因を決定する.
主な方法:
- マサチューセッツ州3つの町 (1969-1991) の飲料水における銅濃度の遡及分析.
- 8.5-8.8 mg Cu/Lの飲料水に曝された6歳未満の子供の死亡率データに関する調査.
- 以前の非インディアンの小児性肝硬変に関する症例報告のレビュー.
主要な成果:
- 6万4千124人の子供年において,高銅の飲料水 (8.5〜8.8 mg Cu/L) に曝露されたとき,肝硬変または肝疾患による死亡は観察されなかった.
- 以前の非インディアンの子供の肝硬変の報告には,潜在的な遺伝的傾向を持つ乳児が含まれていました.
- 高銅曝露にもかかわらず,肝硬変の発生率は増加しませんでした.
結論:
- 飲料水に含まれる高レベルの銅は,非インディアンの子供の肝硬変の原因である可能性は低い.
- 非インディアンの子供の肝硬変は遺伝的疾患であり,環境有毒性の問題ではないようです.
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