魚油は,冠動脈血管新生手術後の回復を防ぐことができますか?
A Leaf1, M B Jorgensen, A K Jacobs
1Massachusetts General Hospital, Charlestown 02129.
Circulation
|November 1, 1994
まとめ
高用量のオメガ3脂肪酸サプリメントは,皮膚経由の内冠動脈血管形成術 (PTCA) の後のレステノシスを予防しませんでした. この大規模な研究では,PTCAを受けた患者におけるレステノシス率の低下において,魚油の恩恵は認められませんでした.
科学分野:
- 心血管科学の研究について
- 栄養科学とは,栄養科学である.
- 介入性心臓病学 介入性心臓病学
背景:
- 魚油のオメガ3脂肪酸は,動脈硬化因子を調節する.
- 血管新生手術後のレステノシスは,アテロゲネシスとの特徴を共有しています.
- 血管新生手術後の回復症を予防する魚油の可能性は,現在調査中です.
研究 の 目的:
- オメガ3脂肪酸のサプリメントが,皮膚経口内冠動脈血管新生手術 (PTCA) の後のレステノシスの予防における有効性を評価する.
主な方法:
- 551人の患者が参加したランダム化試験で,470人がPTCAを成功裏に完了した.
- 患者は6ヶ月間,毎日8gのオメガ3脂肪酸 (EPA/DHA) またはトウモロコシ油を摂取しました.
- レステノシスは6ヶ月後に定量冠動脈血管撮影で評価されました.
主要な成果:
- レステノシス率は,トウモロコシ油グループでは46%で,魚油グループでは52%でした (P = .37).
- 魚油サプリメントの高い適合性は,血と赤血球のリンパ脂質分析によって確認されました.
- アルファトコフェロールのサプリメントは,レステノシス率に影響を与えませんでした.
結論:
- オメガ3脂肪酸の8g/dayのサプリメントは,PTCA後のレステノシスの高い割合を防ぐことに失敗しました.
- 高用量のオメガ3脂肪酸サプリメントと関連した副作用は認められませんでした.
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