口服避妊薬の使用と子宮頸部腺がん

G Ursin¹, R K Peters, B E Henderson

¹Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles 90033-9987.

Lancet (London, England)

|November 19, 1994

まとめ

経口避妊薬の使用は,特に12年を超える長期使用で,子宮頸部腺がんのリスクが2倍に増加するとの関連があります. この発見は,子宮頸部の健康に対する経口避妊薬に関連する潜在的なリスクを強調しています.

科学分野:

婦人科腫瘍学婦人科腫瘍学
エピデミオロジーエピデミオロジー
公衆衛生は公衆衛生である.

背景:

子宮頸部腺癌の発生率は,米国の若い女性において有意に増加した.
この増加は,経口避妊薬の普及と一致した.
以前の研究では,経口避妊薬の使用とこのがんの間の潜在的な関連が示唆されていました.

研究の目的:

経口避妊薬の使用と子宮頸部の腺がんとの関連性を調査する.
経口避妊薬の使用期間が,子宮頸部腺癌のリスクを影響するかどうかを判断する.

主な方法:

ロサンゼルス郡がん監視プログラム (1977-1991) のデータを分析したケース・コントロール研究.
子宮頸部腺癌の195例と386匹の対照群を含む.
個人的なインタビューを通じて,医療,性,避妊,生殖に関する詳細な経歴を収集した.

主要な成果:

口服避妊薬を使用したことがある人は,決して使用していない人と比較して,子宮頸部腺がんのリスクが2.1倍増加した.
12年以上経った経口避妊薬の使用は,調整されたオッズ比率4.4.で,最も高いリスクを示しました.
妊娠開始時の年齢,妊娠に相対するタイミング,または期間が考慮されたときの特定の配方に基づいて,有意な追加のリスクは見つかりませんでした.

結論:

口服避妊薬の使用,特に長期間使用は,子宮頸腺がんの重要なリスク要因です.
発見は,経口避妊薬と子宮頸部腺がんを結びつけるメカニズムに関するさらなる研究が必要であることを示唆しています.
公衆衛生戦略では,経口避妊薬の使用が子宮頸がんリスクに及ぼす長期的な影響を考慮する必要があるかもしれません.

さらに関連する動画

09:48

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

Published on: September 12, 2019

10:42

Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion

Published on: July 6, 2022

関連する概念動画

02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

01:27

Ovarian Cycle

The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...

01:30

Hormonal Control of the Ovarian Cycle

The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...

01:22

Birth Control Methods

Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although vasectomy...

01:24

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...

関連する実験動画