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Updated: Aug 2, 2026

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells
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インテグリン媒介の信号伝導は,GRB2が焦点粘着キナーゼと結合することで,Ras経路と結びついている

D D Schlaepfer1, S K Hanks, T Hunter

  • 1Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92186.

Nature
|December 22, 1994
PubMed
まとめ

フィブロネクチンがインテグリンと結合すると,焦点粘着キナーゼ (FAK) 信号伝達が活性化されます. これは細胞の結合を促進し,GRB2とc-Srcの相互作用を通じてRas/MAPK経路を活性化します.

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