ストレスで活性化されたタンパク質キナーゼの活性化は,MEKK1がアクティベーターSEK1をリン酸化することによって行われる

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Updated: Jul 24, 2026

Assaying Protein Kinase Activity with Radiolabeled ATP
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Assaying Protein Kinase Activity with Radiolabeled ATP

Published on: May 26, 2017

M Yan1, T Dai, J C Deak

  • 1Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106.

Nature
|December 22, 1994
PubMed
まとめ

MEKキナーゼ-1 (MEKK) は,MAPKではなく,Junアミノ端末キナーゼとも呼ばれるストレス活性化タンパク質キナーゼ (SAPK) を活性化します. MEKKはSEK1をリン酸化し,SEK1はSAPKを活性化させ,新しいシグナリングカスケードを明らかにする.

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