嗅覚球への感覚投影のトポグラフィ的組織
R Vassar1, S K Chao, R Sitcheran
1Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032.
Cell
|December 16, 1994
まとめ
特定の嗅覚受容体を発現するニューロンは,単一または数個の嗅覚球球球体に収束する. この発見は,脳内の匂いの表現のための地形図モデルを裏付けている.
科学分野:
- 神経科学は神経科学である.
- 嗅覚系の研究 嗅覚系の研究
- 感覚神経細胞の生物学について
背景:
- 脳が匂いをどう処理するかを理解することは極めて重要です.
- 嗅覚ニューロンによって発現するオロラント受容体 (ORs) は,匂いを検知する鍵です.
- 嗅覚球内のこれらのニューロンの投影パターンは,まだ完全に理解されていません.
研究 の 目的:
- 特定の嗅覚受容体を発現する感覚神経が,嗅覚球内の共通の標的部位にアクソンを投影するかどうかを調査する.
- これらの投影パターンが個体間および脳半球間において一貫しているかどうかを判断する.
主な方法:
- in situ ハイブリダイゼーション技術が利用されました.
- 5つの異なる匂い受容体探査機を使用した.
- 嗅覚球内のアクソン端末の位置を調べました.
主要な成果:
- 特定の嗅覚受容体を発現するニューロンのアクソンが,特定のグルメリウム1つまたは数つに収束することを示した.
- これらの球球の位置が双方向対称であることを明らかにした.
- 同じ種内の個体間でグローメリウルの位置が一貫していることが確認されました.
結論:
- 同じ嗅覚受容体を発現する感覚ニューロンは,限られた,保存された群のグルメルにプロジェクトします.
- この収束は,特定のオドラントが,グルメリュルの異なる地形パターンを活性化するモデルをサポートしています.
- 嗅覚球の匂いの表現のための空間的に組織された地図を示唆します.
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