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Updated: Jul 10, 2026

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes
11:42

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes

Published on: November 1, 2012

ユカリオットDNAポリメラーゼプロセシビティ因子PCNAの結晶構造

T S Krishna1, X P Kong, S Gary

  • 1Laboratories of Molecular BIophysics, Rockefeller University, New York, New York 10021.

Cell
|December 30, 1994
PubMed
まとめ

DNA複製の重要なタンパク質である増殖細胞核抗原 (PCNA) の結晶構造は,DNAを囲む環状の形成を明らかにします. この構造はバクテリアの構造に類似しており,DNA複製の保存メカニズムを示唆しています.

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The Replisome

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Translesion DNA Polymerases

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Restarting Stalled Replication Forks

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The Replisome03:01

The Replisome

DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with the...
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Nucleic Acid Structure

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