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Updated: Aug 18, 2026

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli
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The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

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ヘテロログの宿主体における完全なマクロラクトンの生物合成を工夫した

C M Kao1, L Katz, C Khosla

  • 1Department of Chemical Engineering, Stanford University, CA 94305-5025.

Science (New York, N.Y.)
|July 22, 1994
PubMed
まとめ

研究者らは,新しい宿主における6デオキシエリトロノリドB合成酵素 (DEBS) の全容を用いて,6デオキシエリトロノリドB合成酵素 (6dEB) と関連する化合物を合成した. この遺伝子工学のアプローチは,新しいポリケチド構造の合理的な設計を可能にします.

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Site-Specific Lysine Lactylation via Genetic Code Expansion in E. coli and Mammalian Cells

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