普通の体重の女性の胆石の説明は,腸内経路が遅いということです
K W Heaton1, P M Emmett, C L Symes
1University Department of Medicine, Bristol Royal Infirmary, UK.
Lancet (London, England)
|January 2, 1993
まとめ
胆石を患っている正常体重の女性は,しばしば腸内経路が遅い経験をする. この研究では,これらの女性において,対照群と比較して,全腸通過時間 (WGTT) が著しく長くなることが判明し,胆石形成の潜在的な原因を示唆しています.
科学分野:
- 胃腸内科 胃腸内科
- 胆汁系の研究 胆汁系の研究
- 代謝および内分泌の障害
背景:
- 肥満は胆石の主要な危険因子ですが,正常体重の女性におけるその役割は不明です.
- 以前の生化学的研究は,ゆっくりとした腸内経路と,胆石の前駆体であるリトゲン胆汁を関連付けています.
- 肥満でない人における胆石の病因は,さらなる調査が必要である.
研究 の 目的:
- 胆石を患っている正常体重の女性が異常なほど腸内経路が遅いという仮説を検証するためです.
- 肥満のない女性の胆石の潜在的な原因を特定するために.
主な方法:
- イギリスのブリストルで,胆石を検出するためにコレサイストソノグラフィを使用した,1058人の女性 (25~69歳) を対象とした人口調査.
- 全腸経路時間 (WGTT) の測定は,胆石を患った正常体重の15人の女性と,年齢を合わせた対照群で実施した.
- WGTTは直接測定または排便記録から計算される.
主要な成果:
- コントロール群 (63時間) と比較して,正常体重の女性で胆石 (82時間) が有意に長い平均WGTTが観察されました.
- 胆石を患った女性は,対照群 (141g/24h) よりも,便量が (74g/24h) 大幅に低かった.
- BMI,腰の比率,均等性,トリグリセリド値,アルコール摂取の有意な違いは見つかりませんでした.
結論:
- 胆石を持つ正常体重の女性は,腸内経路が遅いという特徴があります.
- 遅い腸経路は,この集団における胆石形成に寄与する潜在的な要因です.
- 運動障害に関するさらなる研究は,肥満でない個体における胆石の病原性を明らかにする可能性がある.
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