2世紀にわたる近親股関節骨密度の違い
B Lees1, T Molleson, T R Arnett
1Wynn Institute for Metabolic Research, London, UK.
Lancet (London, England)
|March 13, 1993
まとめ
現代の女性は2世紀前の女性よりも骨の減少が速く,骨粗鬆性股関節骨折の増加を説明する可能性がある. この研究では,過去の骨密度を現在のレベルと比較し,有意な違いを強調しました.
科学分野:
- 骨粗鬆症の研究について
- パレオパトロジー (古病理学)
- 骨密度測定法による骨密度測定法
背景:
- 北欧では骨粗鬆性股関節骨折が増加しており,寿命が延びたため増加を上回っています.
- 骨の密度は骨折リスクを決定する重要な要因です.
- 歴史的な骨格の残骸は,骨の健康における長期的な変化を研究するためのユニークな機会を提供します.
研究 の 目的:
- 18世紀から19世紀にかけての股関節の骨の喪失率と,現代の女性の骨の喪失率を比較する.
- 骨粗鬆性股関節骨折の発生率増加に寄与する潜在的な要因を調査する.
主な方法:
- 二重エネルギーX線吸収計 (DXA) を使用して,骨密度を評価しました.
- 1729年から1852年までの骨格サンプル (ロンドン・スピタルフィールドス) を,当時の女性の骨密度と比較した.
- 分析には,閉経前および閉経後のグループが含まれており,閉経時の年齢に対する感度分析が行われました.
主要な成果:
- 2世紀前の女性と比較して,現代の女性は骨の喪失率が著しく高い (p <0.05 閉経前,p <0.01 閉経後).
- 現代の女性における骨の喪失の加速は,ウォードの三角領域で観察され,異なる推定閉経年齢にわたって持続しました.
- これらの発見は,骨の喪失率における歴史的差異が,現代の股関節骨折の増加に寄与する可能性があることを示唆しています.
結論:
- 歴史的な集団と比較して,現代の女性における骨の喪失の加速は,骨粗鬆性骨折の発生率の増加を部分的に説明する可能性がある.
- 現代の女性の身体活動の低下は,骨の損失の増加に寄与する潜在的な要因です.
- 時間の経過とともに,これらの観察された骨の喪失率の違いの正確な理由を明らかにするために,さらなる研究が必要である.
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