染色体11q13とアトピーがアトピー性エクゼマの基礎となっている
R Coleman1, R C Trembath, J I Harper
1Department of Dermatology, Hospitals for Sick Children, London, UK.
Lancet (London, England)
|May 1, 1993
まとめ
この研究では,アトピーの遺伝的基礎を調査し,特に染色体11q13を調査しました. 発見は,この地域がアトピー病に対する主要な感受性の場所を持っていないことを示唆しているが,母親の影響はさらなる調査を正当化している.
科学分野:
- 遺伝学 遺伝学とは
- 免疫学 免疫学とは
- 皮膚科 皮膚科について
背景:
- アトピー性呼吸器疾患は,染色体11q13.3との遺伝的関連性を示しています.
- アトピー性湿疹は,アトピーの一般的な表れである.
研究 の 目的:
- アトピー感受性における染色体11q13の役割を調査する.
- アトピー性エクゼマの多重家族における遺伝的関連性を分析する.
主な方法:
- 95のマルチプレックスファミリーを,アクティブなアトピー性湿疹のプロンバードを通じて募集しました.
- アトピーと11q13.染色体上のマーカーとの関連分析を行った.
- 影響を受けた兄弟のペアにおけるアレル共有を分析し,親のアトピー現象型によって層分化した.
主要な成果:
- リンク分析では,11q13.のアトピーに対する主要な感受性の場所を除外した.
- 影響を受けた兄弟ペアによるアレル共有の有意な偏差は観察されなかった.
- 影響を受けていない父親の家族では,ポジティブなロドスコア (0.8) が認められ,母親の影響の可能性を示唆した.
結論:
- 染色体11q13は,アトピーに対する主要な感受性の場所を含んでいる可能性は低い.
- アトピーの遺伝に対する母子の影響は排除できないため,さらなる研究が必要である.
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