ディフテリア,テタヌス, pertussisワクチンの加速免疫に対する抗体反応
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Updated: Nov 10, 2026

11:49
Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
1Immunisation Division, PHLS Communicable Disease Surveillance Centre, London, UK.
Lancet (London, England)
|July 24, 1993
まとめ
加速されたディフテリア,テタヌス, pertussis (DTaP) ワクチン接種スケジュールは,初期抗体濃度の低下をもたらしました. しかし,加速されたDTaPスケジュールを受けた子供の抗体レベルは,1年後に保護的であり続けました.
科学分野:
- 免疫学 免疫学とは
- 小児科は小児科です.
- ワクチン学 ワクチン学
背景:
- 1990年5月,ディフテリア・テタヌス・ pertussis (DTaP) ワクチン接種のための新しい加速スケジュールが実施されました.
- 初期報告では,加速スケジュールを服用した子供たちの抗体濃度が低いことが示唆された.
研究 の 目的:
- DTaP予防接種後の抗体応答と持続性を評価するために,広範囲の間隔と加速されたスケジュールを使用します.
- 加速スケジュールが保護性抗体レベルに影響を与えるかどうかを判断する.
主な方法:
- 加速された (2,3,4ヶ月) と広く間隔された (15,21,45週間) DTaP スケジュールを受けた子供における抗体濃度を比較した制御研究.
- 固体相放射性免疫測定法 (SP-RIA) で測定されたディフテリア,テタヌス, Bordetella pertussis filamenus hemagglutinin (FHA) に対する抗体レベル.
主要な成果:
- ワクチン接種後6~8週間,加速スケジュールで接種した子どもは,,喉,FHAに対する抗体濃度が著しく低下した.
- 12ヵ月後,抗体濃度の差は縮小し,すべての子どもは保護的な破傷性タタヌス抗体のレベルを維持しました.
- 両グループの少数の子どものみが,12ヶ月後には,喉病の抗体濃度が保護レベルを下回っていた.
結論:
- 加速されたDTaPワクチン接種スケジュールは,保育園のブースター接種の前に,無防備の子供の有意な増加をもたらす可能性は低い.
- この発見は,保護性免疫を維持するための加速DTaP予防接種スケジュールの安全性と有効性を支持しています.
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