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Updated: Jul 20, 2026

Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia
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Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia

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化学的ホメオボックス遺伝子E2A-PBX1は,トランスジェニックマウスにおける増殖,アポトーシス,悪性リンパ腫を誘発する

D A Dedera1, E K Waller, D P LeBrun

  • 1Department of Pathology, Stanford University School of Medicine, California 94305.

Cell
|September 10, 1993
PubMed
まとめ

E2A-PBX1融合遺伝子は,マウスのリンパ腫の急速な発症を引き起こします. この腫瘍遺伝子は逆説的にリンパ性細胞増殖とプログラム細胞死の両方を駆動し,悪性腫瘍につながります.

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Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...