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Updated: Aug 17, 2026

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
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Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications

Published on: January 27, 2014

活性化されたGααsによってNIH 3T3細胞のRas誘発変異を抑制する

J Chen1, R Iyengar

  • 1Department of Biochemistry, Mount Sinai School of Medicine, City University of New York, NY 10029.

Science (New York, N.Y.)
|March 4, 1994
PubMed
まとめ

Gタンパク質αs (Gαs) は,Rasからの細胞増殖信号を抑制し,循環型AMP (cAMP) レベルを上昇させます. この発見は,成長因子のシグナル伝達と細胞成長の調節における重要なメカニズムを明らかにしています.

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