皮質細胞との接触は,サルモネラ型ヒモリウム (Salmonella typhimurium) の表面付属体の形成を誘発する
C C Ginocchio1, S B Olmsted, C L Wells
1Department of Microbiology, State University of New York at Stony Brook 11794-5222.
Cell
|February 25, 1994
まとめ
サルモネラ・タイフィムリウム (Salmonella typhimurium) は,一時的な表面付属体を用いて,非ファゴサイト性宿主細胞を侵略する. これらの構造はバクテリアの侵入に不可欠であり,接触時に形成され,内部化中に消失します.
科学分野:
- 微生物学 微生物学とは
- 細胞生物学 細胞生物学
- バクテリア病原菌の発生
背景:
- サルモネラ・タイフィムリウム (Salmonella typhimurium) は腸内細菌であり,非ファゴサイト細胞に侵入することが可能である.
- バクテリアの侵入は,親密な宿主-病原体相互作用が宿主細胞の信号伝達経路を誘発することを含む.
- これは,膜の乱れと,その後のバクテリアの吸収につながる.
研究 の 目的:
- Salmonella typhimuriumの侵入中に細菌の表面構造が果たす役割を調査する.
- サルモネラ・タイフィムリウムが宿主の上皮細胞に侵入するメカニズムを解明する.
主な方法:
- 高解像度スキャニング電子顕微鏡を用いた.
- サルモネラ・タイフィムリウムが培養された上皮細胞と相互作用する観察.
- 表面オーガネルの形成に欠陥があるサルモネラ変異体の分析.
主要な成果:
- Salmonella typhimuriumは,上皮細胞と接触すると,表面に一時的な付属体を形成します.
- 付属体の形成は新しいタンパク質合成を必要とせず,一時的なものです.
- これらの一時的な構造を欠いた突然変異者は,宿主細胞を侵略する能力が低下した.
結論:
- サルモネラ・タイフィムリウム (Salmonella typhimurium) の一時的な表面付属体は,宿主細胞の侵入に不可欠である.
- これらの構造は,最初の相互作用と非胞細胞への侵入を容易にする.
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