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Updated: May 7, 2026

Examination of Thymic Positive and Negative Selection by Flow Cytometry
14:29

Examination of Thymic Positive and Negative Selection by Flow Cytometry

Published on: October 8, 2012

欠陥のあるT細胞受容体シグナル伝達と,zap-70キナーゼが欠けているヒトにおけるCD8+チミス選択

E Arpaia1, M Shahar, H Dadi

  • 1Division of Immunology and Allergy, Hospital for Sick Children, Toronto, Ontario, Canada.

Cell
|March 11, 1994
PubMed
まとめ

患者における選択性T細胞欠乏症 (STD) は,zap-70キナーゼ変異によるもので,T細胞の発達と機能に影響を及ぼします. このzap-70欠乏症は,CD8 T細胞の成熟とCD4 T細胞のシグナル伝達の両方を阻害し,免疫機能障害を引き起こす.

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