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Updated: Aug 14, 2026

In Situ MHC-tetramer Staining and Quantitative Analysis to Determine the Location, Abundance, and Phenotype of Antigen-specific CD8 T Cells in Tissues
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In Situ MHC-tetramer Staining and Quantitative Analysis to Determine the Location, Abundance, and Phenotype of Antigen-specific CD8 T Cells in Tissues

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細胞内MHCクラスIIコンパートメントの分離と特徴付け

A Tulp1, D Verwoerd, B Dobberstein

  • 1Department of Cellular Biochemistry, Netherlands Cancer Institute, Amsterdam.

Nature
|May 12, 1994
PubMed
まとめ

研究者らは,メジャー・ヒストコンパティビリティ・コンプレックス (MHC) クラスIIの分子が成熟する新しい細胞区画を特定しました. このコンパートメントは,抗原ペプチドが細胞表面に到達する前に,MHCクラスIIの分子にロードするために不可欠です.

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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...